Katharina L. Dürr

Structural biologist — membrane proteins, ion channels & drug discovery

I study the structure and dynamics of membrane proteins using cryo-EM and X-ray crystallography, with a focus on ion channels and transporters relevant to human disease and drug discovery.

University of Oxford, Department of Chemistry

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Highlights

• First structures of an intact AMPA-subtype glutamate receptor — Resolved resting, pre-open and desensitized states, revealing the gating mechanism.
• RESOLUTE consortium — SLC transporters for drug discovery — Contributed to a public-private effort to unlock an under-studied class of drug targets.
• 1,300+ citations · h-index 17 — Across structural and functional studies of membrane transport proteins.

Selected publications

• The RESOLUTE consortium: unlocking SLC transporters for drug discovery · Nature Reviews Drug Discovery, 2020
• X-ray structures of AMPA receptor–cone snail toxin complexes illuminate activation mechanism · Science, 2014
• Structure and dynamics of AMPA receptor GluA2 in resting, pre-open, and desensitized states · Cell, 2014

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